Natural remedies for Anal Itching? Try not to irritate the skin even more by scrubbing the area with soap. This will only cause more irritation and itching. Gentle cleaning with water helps the area heal. Other home therapies include the following: Change to a plain, soft, unscented toilet paper. If toilet paper feels too abrasive, try cleaning with unscented baby wipes or cotton moistened with mineral oil . Dry with cotton afterward to remove any moisture. Many times, baby wipes can exacerbate anal itching if used long-term. Wear loose-fitting cotton underwear that allows sweat to evaporate. Do not wear panty hose. Over-the-counter medicines such as creams containing hydrocortisone or zinc oxide can provide some relief; however, apply sparingly and notify your health care practitioner prior to using them. Avoid food irritants and eat a high-fiber diet .